Sep 26 2009

Acne Vulgaris

Acne is a disease rarely associated with systemic medical problems; however, the importance and morbidity of acne should not be underestimated because its disfiguring can have important negative psychosocial consequences for affected individuals including diminished self-esteem, social embarrassment, social withdrawal, depression and even unemployment [1, 3]. Risk factors/Triggers1. Food/DietFoods such as nuts, cola, milk, cheese, fried foods and iodised salts have been implicated as triggers of acne vulgaris; however, the connections between nutrition and acne has not definitely been proven as they are rarely supported by good analytical, epidemiological or therapeutic studies [4, 5]. On the other hand, recurrent acne as noted by Niemeier et al (2006) may be a cutaneous sign of an underlying eating disorder.2. GeneticsA genetic background is supported by a case control study by Goulden et al, as noted by Rzany et al (2006). This stated that the risk of adult acne vulgaris in relatives of patients with acne as compared with those of patients without acne is significantly higher [4].3. HormonesAccording to Rzany et al (2006), hormonal influences on acne vulgaris are undisputed as shown by the higher incidence of acne in male adolescents. Premenstrual flare has also been recorded as causing acne [5].4. NicotineSmoking has also been named as a risk factor for acne vulgaris; however, conflicting data exists as to the link between smoking and acne. Some population based studies have found links between smoking and acne whilst some others have not [4].Important!Contrary to popular misconceptions by young patients and occasionally their parents, acne does not come from bad behaviour nor is it a disease of poor hygiene. It also has nothing to do with lack of cleanliness [2].Types of acne vulgarisThere are two main types of acne vulgaris, inflammatory and non-inflammatory; these can be manifested in different ways,1. Comedonal acne, which is a non-inflammatory acne2. Papules and pustules of inflammatory acne3. Nodular acne (inflammatory acne)4. Inflammatory acne with hyperpigmentation (this occurs more commonly in patients with darker skin complexions) [1]Clinical manifestationsIn general, acne is limited to the parts of the body, which have the largest and most abundant sebaceous glands such as the face, neck, chest, upper back and upper arms. Among dermatologists, it is almost universally accepted that the clinical manifestation of acne vulgaris is the result of four essential processes as described below [1, 6],1. Increased sebum production in the pilosebaceous follicle. Sebum is the lipid-rich secretion product of sebaceous glands, which has a central role in the development of acne and also provides a growth medium for Propionibacterium acnes (P acnes), an anaerobic bacterium which is a normal constituent of the skin flora. Compared with unaffected individuals, people with acne have higher rates of sebum production. Apart from this, the severity of acne is often proportional to the amount of sebum produced [1, 6]. 2. Abnormal follicular differentiation, which is the earliest structural change in the pilosebaceous unit in acne vulgaris [1].3. Colonisation of serum-rich obstructed follicle with Propionibacterium acnes (P acnes). P acnes is an anaerobic bacterium which is a normal constituent of the skin flora and which populates the androgen-stimulated sebaceous follicle [androgen is a steroid hormone such as testosterone or androsterone, that controls the development and maintenance of masculine characteristics]. Individuals with acne have higher counts of P acnes compared with those without acne [1, 6].4. Inflammation. This is a direct or indirect result of the rapid and excessive increase of P acnes [1]. Non-inflammatory acne lesions include open and closed comedones, which are thickened secretions plugging a duct of the skin, particularly sebaceous glands. Open comedones, also known as blackheads, “appear as flat or slightly raised brown to black plugs that distend the follicular orifices”. Closed comedones, also known as whiteheads, “appear as whitish to flesh-coloured papules with an apparently closed overlying surface” [1]. Inflammatory lesions on the other hand include papules, pustules, and nodules; papules and pustules “result from superficial or deep inflammation associated with microscopic rupture of comedones”. Nodules are large, deep-seated abscesses, which when palpated may be compressible. In addition to the typical lesions in acne, other features may also be present. These include scarring and hyperpigmentation, which can result in substantial disfigurement [1].Psychological AspectsNumerous psychological problems such as diminished self-esteem, social embarrassment, social withdrawal, depression and even unemployment stem from acne. However, differential diagnosis from a psychosomatic point of view indicates two serious psychological problems, which can arise from acne. These are,1. Psychogenic excoriation, and 2. Body dysmorphic disorder (BDD)Psychogenic excoriation also referred to as neurotic excoriation, pathological or compulsive skin picking “is characterised by excessive scratching or picking of normal skin or skin with minor irregularities” [5]. According to Niemeier et al (2006) it is estimated to occur in 2% of dermatological patients. Patients with this disorder can also have psychiatric disorders such as mood and anxiety disorders, as well as associated disorders such as obsessive compulsive disorder, substance abuse disorder, obsessive compulsive personality disorder, compulsive buying, eating disorder, and borderline personality disorder, to mention a few [5]. Body dysmorphic disorder (BDD) “is a condition characterised by an extreme level of dissatisfaction or preoccupation with a normal appearance that causes disruption in daily functioning” [3]. Niemeier et al (2006) described it as “a syndrome characterised by distress, secondary to imagined or minor defects in one’s appearance.” The onset of BDD is usually during adolescence, and it occurs equally in both male and female. Common areas of concern include the skin, hair and nose, with acne being one of the most common concerns with BDD patients [3].According to the Diagnostic and Statistics Manual of Mental Disorders (2000), BDD has three diagnostic criteria,1. A preoccupation with an imagined defect in appearance; where a slight physical anomaly is present, the person’s concern is markedly excessive,2. The preoccupation causes clinically significant distress or impairment in social, occupational, or other important areas of functioning,3. The preoccupation is not caused by another mental disorder (e.g. Anorexia Nervosa)Characteristic behaviours include skin picking, mirror checking, and camouflaging by wearing a hat or excessive make up. Apart from these, patients often seek reassurance frequently by asking questions such as “Can you see this pimple?” or “Does my skin look okay?” Some patients also have a tendency to doctor shop, which is essentially going from one specialist to another in search of a dermatologist or plastic surgeon, willing to carry out a desired procedure or dispense a certain drug, to improve their perceived defect [3, 5].Although it is a relatively common disease, BDD is still an under diagnosed psychiatric disorder and is estimated to affect 0.7 to 5% of the general population. Other psychiatric conditions associated with BDD include major depression, anxiety, and obsessive compulsive disorder. It is also associated with high rates of functional impairment and suicide attempts, high levels of perceived stress, and markedly poor quality of life [3, 5, 8]. Acne Treatment1. Topical treatment, particularly for individuals with non-inflammatory comedones or mild to moderate inflammatory acne (See types of acne vulgaris). Medications include tretinoin (available as gels, creams, and solutions), adapalene gel, salicylic acid (available as solutions, cleansers, and soaps), isotretinoin gel, azelaic acid cream, benzoyl peroxide (available as gels, lotions, creams, soaps, and washes), to mention a few [1, 2].2. Oral treatment, particularly for acne that is resistant to topical treatment or which manifests as scarring or nodular lesions. Medications include oral antibiotics (e.g. tetracycline, doxycycline, minocycline, erythromycin, and co-trimoxazole), oral isotretinoin, and hormonal agents (e.g. oral contraception, oral corticosteroid, cyproterone acetate, or spironolactone) [1, 2].3. Physical or surgical methods of treatment, which are sometimes useful as adjuvant to medical therapy. Methods include comedo extraction, intralesional injections of corticosteroids, dermabrasion, chemical peeling, and collagen injections, to mention a few [1, 9].4. Sun exposure, reported by up to 70% of patients to have a beneficial effect on acne [10].5. Light therapy, which is becoming more popular due to the growing demand for a convenient, low risk and effective therapy, as many patients fail to respond adequately to treatment or develop side effects, from the use of various oral and topical treatments available for the treatment of acne [11]. Methods include the use of visible light (e.g. blue light, blue/red light combinations, yellow light, and green light), laser treatment and monopolar radiofrequency [11]. Many of these light therapy treatments can be used at home.Recommended Products for AcneReferences1. Brown SK, Shalita AR. Acne vulgaris. Lancet 1998; 351:1871-1876.2. Webster GF. Acne vulgaris. Br Med J 2002; 325: 475-479.3. Bowe WP et al. Body dysmorphic disorder symptoms among patients with acne vulgaris. J Am Acad Dermatol 2007; DOI: 10.1016/j.jaad.2007.03.030.4. Rzany B, Kahl C. Epidemiology of acne vulgaris. JDDG 2006; DOI: 10.1111/j.1610-0387.2006.05876.x5. Niemeier V, Kupfer J, Gieler U. Acne vulgaris-Psychosomatic aspects. JDDG 2006; DOI: 10.1111/j.1610-0387.2006.06110.x6. Gollnick H. Current perspectives on the treatment of acne vulgaris and implications for future directions. Eur Acad Dermatol Venereol 2001; 15 (Suppl. 3):1-4.7. American Psychiatric Association. Diagnostic and Statistics Manual of Mental Disorders. 4th Ed. Accessed via: BehaveNet® Clinical CapsuleTM; http://www.behavenet.com/capsules/disorders/bodydysdis.htm. Accessed on: 28th June 2007.8. Phillips KA et al. A retrospective follow-up study of body dysmorphic disorder. Comprehensive Psychiatry 2005; 46: 315-321.9. Taub AF. Procedural treatments of acne vulgaris. Dermatol Surg 2007; 33: 1-22.10. Cunliffe WJ, Goulden V. Phototherapy and acne vulgaris.Br J Dermatol 2000; 142 (5): 855-856.11. Dierickx CC. Lasers, Light and Radiofrequency for treatment of acne. Med Laser Appl 2004; 19: 196-204.DisclaimerThis article is only for informative purposes. It is not intended to be a medical advice and is not a substitute for professional medical advice. Please consult your doctor for all your medical concerns. Kindly follow any information given in this article only after consulting your doctor or qualified medical professional. The author is not liable for any outcome or damage resulting from any information obtained from this article.

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Sep 12 2009

Acne And Vitamin B5 (Pantothenic Acid) Deficiency

Acne Specialist believes there is a correlation between Vitamin B5 deficiency and acne (the most common skin disease), due to modern food processing.
Vitamin B5, aka pantothenic acid, serves the body in many ways. It is a member of the nutritionally elite group of eight vitamins lovingly called the Vitamin B complex. This powerful group of vitamins has a role in nearly every major body system and process. The Vitamin B complex keeps both body and mind functioning and in good health.
Vitamin B5, like all of the vitamins in the B complex, is essential to the body for a number of reasons (also see other sections of acne-specialist.com for more information):
-Pantothenic acid as coenzyme A is closely involved in adrenal cortex function and has come to be known as the “antistress” vitamin. It supports the adrenal glands to increase production of cortisone and other adrenal hormones to help counteract stress. Coenzyme A is vital in the synthesis of fatty acids, cholesterol, steroids, sphingosines, and phospholipids. It also helps synthesize porphyrin, which is connected to hemoglobin.
-Through the above mechanism, Vitamin B5 is also thought to help prevent aging and wrinkles and is important for hair and healthy skin. As you can imagine, it is used in a variety of cosmetic products.
-It has the ability to utilize the food it takes in as fuel for its myriad of processes, great and small. As the coenzyme, Vitamin B5 is important in cellular metabolism of carbohydrates and fats to release energy.
-It works in the regular maintenance and repair of all bodily tissues, from the cellular level on up. This makes it a critical part of the body’s efforts to fight the physical damage to which excessive stress contributes.
-Vitamin B5 serves many important functions in the nervous system — for example, Vitamin B5 contributes to the production of neurotransmitters, which are important to the ability of the nerves to communicate.
-Through its adrenal support, Vitamin B5 may reduce potentially toxic effects of antibiotics and radiation.
-Vitamin B5, acting as a cofactor or partner to other members of the Vitamin B complex as well as other nutrients, has a great role in the functioning of the adrenal glands and also promotes normal growth of the body. This is due to its role in hormone production throughout the body.
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B5 is stable to moist heat and oxidation or reduction (adding or subtracting an electron), though it is easily destroyed by acids (such as vinegar) or alkalis (such as baking soda) and by dry heat. Over half of the pantothenic acid in wheat is lost during milling, and about one-third is degraded in meat during cooking. In many whole foods, Vitamin B5 is readily available.
Only recently the general public is becoming more aware of the importance of whole foods. Yet, diets of the majority of the population are still made up of mostly heavily processed foods (available Vitamin B5 activity is lost during refinement of foods) due to our fast pace, time poor lifestyle of the modern world.
“NO WONDER THE SERIOUS GLOBAL ACNE PROBLEM, PARTICULARLY AMONGST DEVELOPED NATIONS!!!”
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Vitamin B5 / pantothenic acid is found in yeasts, molds, bacteria, and plant and animal cells, as well as in human blood plasma and lymph fluid.
Good sources of pantothenic acid include the organ meats, brewer’s yeast, egg yolks, fish, chicken, whole grain cereals, cheese, peanuts, dried beans, and a variety of vegetables, such as sweet potatoes, green peas, cauliflower, and avocados. Vitamin B5 is also made by the bacterial flora of human intestines, another source for this important metabolic assistant or coenzyme.
Fatigue is probably the earliest and most common symptom of pantothenic acid deficiency. A diet high in refined and processed foods or a reduction or destruction of intestinal flora, most commonly by antibiotic use, can lead to a vitamin B5 deficiency.
Teenagers are more likely to experience a deficiency, because their diets often include high amounts of “fast foods” sugars, and refined flours (all low in B vitamins). And the problem may be compounded because the acne often associated with this type of diet is commonly treated with tetracycline antibiotics, which reduce the intestinal bacteria and thereby the production of pantothenic acid in the colon.
Studies of pantothenic acid deficiency in rats showed increased graying of the fur, decreased growth, and, in the extreme, hemorrhage and destruction of the adrenal glands. In humans, the decreased adrenal function caused by B5 deficiency can lead to a variety of metabolic problems. Fatigue is most likely; there may also be physical and mental depression, a decrease in hydrochloric acid production and other digestive symptoms, some loss of nerve function, and problems in blood sugar metabolism, with symptoms of hypoglycemia (low blood sugar) being the most common. Pantothenic acid affects the function of cells in all systems, and a deficiency may reduce immunity, both cellular and antibody responses. Other symptoms of B5 deficiency include vomiting, abdominal cramps, skin problems, tachycardia, insomnia, tingling of the hands and feet, muscle cramps, recurrent upper respiratory infections, and worsening of allergy symptoms.
Therapeutic ranges are more like 250-500 mg daily and even higher, taken, of course, along with the other B complex vitamins. Individual needs vary according to food intake, degree of stress, and whether one is pregnant or lactating. Those people who eat a diet of processed foods, have a stressful lifestyle, or have allergies require higher amounts of pantothenic acid.
As with other B vitamins, there are no specific toxic effects from high doses of pantothenic acid. Over 1,000 mg daily has been taken for over six months with no side effects; when 1,500 mg or more is taken daily for several weeks, some people experience a superficial sensitivity in their teeth. However, it is possible that if B5 is taken without other B vitamins, it may create metabolic imbalance.


May 31 2009

How to Remove Pimples - Success!

facialgirlWell, believe it or not, my daughter and I are both currently acne free.  ACNE FREE.  We’ve been trying a new regimen that teaches how to remove pimples for 3 days now and it’s almost too good to be true.

Like everything else, we got it off the internet.  It’s actually a system that’s in ebook form.  I can’t give it away though, or the owner of the system will probably sue me or something, but I can tell you this much, it’s dietary.

So, basically through dietary changes, my daughter and I have been able to clear up our acne in just a few days. This has been an uphill climb, with us already spending tons of cash and doing every crazy home treatment we could find.

Of course we’re skeptical.  I’m not sure how long this can last.  But for now, we are both thrilled! I’ll update soon and let you guys know how it’s going.

Click here if you want to see the system we are using to get rid of our acne.

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